Propylene Glycol as a Pharmaceutical Excipient in Pediatrics

Propylene Glycol as a Pharmaceutical Excipient in Pediatrics Disha Patel The Utilization of Propylene Glycol as a Pharmaceutical Excipient in the Pediatric Field Abstract As a widely used excipient in pediatric formulations, propylene glycol functions as a solvent, emulsifier, humectant, and hygroscopic agent. It is a clear, colorless liquid whose properties enable it to have pharmacodynamic applications. Oftentimes, propylene glycol is combined with other mediations to enhance its penetration. For instance, a combination of 20% propylene glycol and 5% lactic acid in a semiocculusive cream base is used as a highly effective and well-tolerated keratolytic in patients with lamellar ichthyosis and possibly could be in various other hyperkeratotic diseases. Unfortunately, though to a lesser degree, this excipient is associated with toxic effects such as hyperosmolality, hemolysis, and lactic acidosis. Also, in concentrations greater than 10%, propylene glycol may act as an irritant in some patients (Health Effects 2). From a pharmacokinetic viewpoint, there is a potential of renal toxicity associated with propylene glycol and lorazepam. The high concentra tion of propylene glycol contained in certain intravenous drug products, such as phenytoin, diazepam, digoxin, and etomidate, may induce thrombophlebitis. Here, the patients increased serum creatinine concentrations are likely to have resulted from exposure to propylene glycol due to lorazepam infusion. Serum osmolality and osmol gap may be useful markers for propylene glycol toxicity. Much like the above mentioned applications, through its chemical composition, propylene glycol has the ability to exert a beneficial effect on pediatric formulations (Webbook 5). Introduction Propylene glycol, which is also known Propane-1,2-diol, is a colorless, viscous, organic liquid with a slightly sweet taste. This excipient is utilized in food, cosmetics and pharmaceutical preparations. Examples of pharmaceutical applications include therapeutic drugs such as vaccines, cough syrups, local anesthetics, antiseptics, vitamins, and hormones. It is produced through the fermentation of yeast and carbohydrates. Propylene glycol is industrially made from propylene oxide. It is made from either a catalytic or a non-catalytic method which exposes the propylene into extremes of temperature and a small amount of sulfuric acid or alkali to yield propylene glycol for industrial purposes (Frequently Asked Questions about Propylene Glycol 1). It is concluded that, with extensive research, this excipient is categorized as safe in the body. According to the Agency for Toxic Substances Disease Registry, in the body, under conditions of normal low exposure, propylene glycol is quickly metabolized and excreted. Its metabolic pathway is comparable to that of sugar: propylene glycol is quickly converted into lactic acid, similar to what happens with the energy in the muscles when exercising. Afterwards, the lactic acid is excreted via urine (Database of Select Committee on GRAS Substances (SCOGS) Reviews 2). Surprisingly, from a toxicological point of view, alcohol is more toxic than propylene glycol. Propylene glycol has been used safely for more than 50 years in a large variety of applications. As a result, it is effectively used in prescription medications such amoxicillin (500 mg), clindamycin hydrochloride (150 mg 300 mg), gabapentin (300 mg), lyrica (50 g 75 mg), and omeprazole (20 mg) (Result Filters 4). Through statistical data, it is overwhelmingly evident that there is a continually growing market for propylene glycol. According to the IHS website, United States (19%), Western Europe (39%), Japan (17%), and China (80%) had the largest consumption (Inactive Ingredients in Pharmaceutical Products 5). Since it has been proven safe with a relative low toxicity level, it is projected that the consumption of propylene glycol will rise (IHS Home Page 4). The Effects of Propylene Glycol in Pediatrics Pharmaceutical medications are composed of two very essential ingredients: active pharmaceutical ingredients (APIs) and excipients. The purpose of the active pharmaceutical ingredient in a drug is to elicit a specific therapeutic effect on the patient. Specifically, when the drug is consumed, it will exert a necessary effect on the body in order to produce an ideal outcome: the therapeutic response (TOXICOLOGICAL PROFILE FOR PROPYLENE GLYCOL 3). The component of the drug is the excipient, which is an inactive ingredient utilized for possible multifunctional usage. For instance, an excipient can be binders, coatings, diluents, disintegrants, fillers, flavors, colors, lubricants, glidants, sorbents, preservatives, sweeteners, and solubilizing agents. Oftentimes, they do acquire some extent of therapeutic acclivity, though less than the API. Similar to many other drugs, propylene glycol functions both, as an API and excipient-an indication that multiple functions can have multiple benef its (AccessMedicine [41168448] 2). Additionally, medications are tailored to a specific age group to maximize the therapeutic effect for the patient. Therefore, criteria for an ideal drug for the pediatric population will undoubtedly differ from the criteria for the geriatric population. Routes of administration suitable for pediatrics include oral, topical, rectal, inhalation, injectable and drop (eye, ear, and nose). Propylene glycol enters the body as an alcohol and metabolizes in the bodys enzyme pathways. These pathways do not mature in humans until 12 to 30 months of age. Proper judgment when administering a propylene glycol-based formulation to neonates is crucial in order to prevent potential complications (PubChem 1). In comparison to adults, new born babies have a propylene glycol half-life of 16.9 hours rather than a significantly lower 5 hour half-life for adults. In one study, the use a multivitamins whose contents included propylene glycol resulted in serum osmolality in low-birth-weight premature babies. However, in another research activity, phenobarbital injections containing propylene glycol were deemed to have an inconsequential effect on the osmolar gap (AccessMedicine [40400741] 4). A higher amount of propylene glycol delivered per dose, such as 3 grams, is known to cause more seizures in infants, in comparison to those receiving lesser amounts per dose, such as 300 mg. In a population of 262 patients treated for burns, roughly 3 percent were the result of topical propylene glycol which resulted in hyperosmolality (Potential Safety Concerns with the Large Amount of Propylene Glycol 2). Since propylene glycol is a liquid excipient, it affects the gastrointestinal tract. However, studies of people and animals show that if you have repeated eye, skin, nasal, or oral exposures to propylene glycol for a short time, you may develop some irritation. Furthermore, extensive studies performed have concluded that there are no severe risks of propylene glycol in infants. Thus, it is assumed to be safe if consumed in moderation. The oral liquid formulation also illustrates a high compliance rate amongst infants. Simple considerations such as route of administration and effective concentrations can help achieve a therapeutic response (AccessMedicine [40400741] 6). The chemical composition of propylene glycol is relatively simple: alcohol groups with a hydrocarbon backbone. To an extent, this simplistic structure plays a broad role in various applications ranging from industrial to pharmaceutical uses. Generally, neonates can be exposed to propylene glycol orally or topically. Absorption through oral intake is significantly more effective than on the skin. Once propylene glycol reaches the site of action, it is rapidly metabolized and subsequently excreted (A-Z Index 9). In the blood stream, the half-life of the excipient is approximately 2-4 hours in adults. However, in neonates, it is drastically longer (17 hours). Pertaining to its mechanism of action, it is further metabolized to lactate which is further metabolized to pyruvate, carbon dioxide, and water. Through utilization of the gluconeogenic pathway, glucose is formed. Even though the safety the propylene is apparent, extremely large exposures to propylene glycol have the potential to r esult in lactic acidosis and hyperosmotic changes in the blood (Health Effects 4). Extensive research has provided sufficient evidence on the safety and quality of this excipient. To begin, numerous sources indicate that propylene glycol has a dramatically low degree of toxicity. It is associated with moderately low concern for acute toxicity by ingestion, skin contact, and inhalation. There have been reports of altered nervous system function because of high oral exposure to propylene. Normal metabolism of this excipient can be negatively affected through blood pH and osmotic changes. Furthermore, animal studies also confirm the relative low risk of propylene glycol (Webbook 2). For example, a longitudinal study performed on rodents with extremely high exposures to the excipient presented no indication of adverse effects. Consequently, a similar study performed on cats illustrated hematological changes. High aerosol concentrations inhaled by rats caused minor nasal and ocular signs that may have been due to mild irritation or drying effects of propylene glycol on mucous membranes. On a positive note, there is no correlation to cancer from the use of propylene glycol (AccessMedicine [45774923] 1). Pharmacological Profile of Propylene Glycol Propylene glycol, with a formula C3H8O2, is readily miscible with water, acetone, and chloroform. In reference to its structure, it contains an asymmetrical carbon atom, so it has two enantiomers. Since the commercial product is a racemic mixture, pure optical enantiomers can be achieved by the hydration of optically pure propylene oxide. Upon the mixture of propylene glycol and water, the freezing point of water is drastically depressed. Because of this, it is used as a de-icing fluid for vehicles. With the exception of ethylene glycol, glycols are generally known to be non-corrosive and have low volatility and toxicity. Even with the strict criteria established for pediatrics, propylene glycol satisfies the requirements for safe administration to pediatric patients (A-Z Index 5). Furthermore, it is derived from propylene oxide and its production methods include either catalytic- proceeds at 150  °C to 180  °C in the presence of ion exchange resin or a small amount of sulfuric acid or alkali, or non-catalytic- high-temperature process at 200  °C to 220  °C (IHS Home Page 3). Even though this paper focuses mainly on propylene glycol’s purpose as an excipient in pediatric formulations, it has an overwhelmingly degree of other applications. A certain amount (45%) is used as chemical feedback for the manufacture of unsaturated polyester resins. Chemically speaking, propylene glycol reacts with a mixture of unsaturated maleic anhydride and isophthalic acid to give a copolymer. Continuing further crosslinking, thermoset plastics are produced from the unsaturated polymers. Similarly, propylene glycol also reacts with propylene oxide to produce oligomers as well as polymers that are utilized to form polyurethanes (Frequently Asked Questions about Propylene Glycol 2). As proven be multiple research articles, this excipient is proven safe. The extent of safety is measured by plasma concentration: â€Å"Serious toxicity generally occurs only at plasma concentrations over 1 g/L, which requires extremely high intake over a relatively short period of time.† However, there is always an uncertainty and accidental occurrences. For instance, rare cases of propylene glycol poison were largely related to either inappropriate intravenous administration or accidental ingestion of enormously large quantities by children (Hazardous Substance Fact Sheet 9). Conclusion As proven through this research paper, propylene glycol is an effective ingredient for pediatric use. Since there was no established linkage between cancer and its use, it is popular for multiple uses. Several considerations should be utilized in formulating pediatric medications-specifically, the ingredients in the formulation. With its multiple uses, propylene glycol is well-suited for children for its safety and effectiveness. Like all ingredients, propylene glycol may produce adverse effects in the patient, but drastically less harmful than others. Since an enormous quantity must be consumed before toxicity level is reached, it is well suited for children. With viscous properties, upon consumption, it has the potential to elicit a faster therapeutic effect on the patient. Therefore, it is both potent and efficacious. In all, this ingredient proves to be a significant element to the overall formulation of a medication, regardless of the age group targeted (Webbook 5). Bibliography A-Z Index. ATSDR. N.p., n.d. Web. 13 Apr. 2014. http://www.atsdr.cdc.gov/phs/phs.asp?id=1120tid=240>. Database of Select Committee on GRAS Substances (SCOGS) Reviews. AccessData. N.p., n.d. Web. 13 Apr. 2014. http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListingid=262>. Frequently Asked Questions about Propylene Glycol. N.p., n.d. Web. 13 Apr. 2014. http://www.propylene-glycol.com/uploads/PropyleneGlycolAdvocacybrochure.pdf>. Hazardous Substance Fact Sheet. New Jersey Department of Health. N.p., n.d. Web. 13 Apr. 2014. http://nj.gov/health/eoh/rtkweb/documents/fs/3595.pdf>. Health Effects. ATSDR. N.p., n.d. Web. 13 Apr. 2014. http://www.atsdr.cdc.gov/ToxProfiles/tp189-c2.pdf>. InactiveIngredients in Pharmaceutical Products: Update (Subject Review). Peditrics. N.p., n.d. Web. 13 Apr. 2014. http://pediatrics.aappublications.org/content/99/2/268.full#sec-11>. Potential Safety Concerns with the Large Amount of Propylene Glycol. Natap. N.p., n.d. Web. 13 Apr. 2014. http://www.natap.org/2000/may/potential_safety051500.htm>. Propylene Glycol. PubChem. N.p., n.d. Web. 13 Apr. 2014. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1030>. Propylene Glycol. Webbook. N.p., n.d. Web. 13 Apr. 2014. http://webbook.nist.gov/cgi/cbook.cgi?ID=C57556Mask=8>. Propylene Glycols. IHS Home Page. N.p., n.d. Web. 13 Apr. 2014. http://www.ihs.com/products/chemical/planning/ceh/propylene-glycols.aspx>. Result Filters. National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 13 Apr. 2014. http://www.ncbi.nlm.nih.gov/pubmed/14524641>. St. Johns University Academics Schools Libraries. AccessMedicine. N.p., n.d. Web. 13 Apr. 2014. http://accessmedicine.mhmedical.com.jerome.stjohns.edu/content.aspx?bookid=348sectionid=40381672jumpsectionID=40400741>. St. Johns University Academics Schools Libraries. AccessMedicine. N.p., n.d. Web. 13 Apr. 2014. http://accessmedicine.mhmedical.com.jerome.stjohns.edu/content.aspx?bookid=388sectionid=45764289jumpsectionID=45774923>. St. Johns University Academics Schools Libraries. AccessMedicine. N.p., n.d. Web. 13 Apr. 2014. http://accessmedicine.mhmedical.com.jerome.stjohns.edu/content.aspx?bookid=392sectionid=41138958jumpsectionID=41168448>. TOXICOLOGICAL PROFILE FOR PROPYLENE GLYCOL. Agency for Toxic Substances and Disease Registry. N.p., n.d. Web. 13 Apr. 2014. http://www.atsdr.cdc.gov/toxprofiles/tp189.pdf>.

E Health Is Combined Use Of Electronic Information Technology Essay

E Health Is Combined Use Of Electronic Information Technology Essay Health is a major concern for everyone in this world. The implementation of Information and Communication Technologies in the medical field has modified the present definition of health care. It suggested the solution that can benefit both patient as well as health care professionals. eHealth provides solutions in a wide spectrum and it includes various health care products, systems and services. It includes tools for health professionals as well as for patients and citizens. Various services or systems that are covered under eHealth are; health information networks, electronic health records, telemedicine services, Consumer health informatics, Healthcare Information Systems, Health knowledge management. Patients share their health information with their physician in order to improve their health treatment. Patients Information is stored in Electronic Health Record. It has been observed from a survey conducted in Sweden that 95% of all documentation in primary care is made in electronic healthcare records (1). Almost 55% of the Pharmaceutical prescriptions are issued digitally in Sweden and transmitted directly to the pharmacy store (1). The challenging issue which is associated with the eHealth system is the protection of Medical Records. Since the data is transmitted over the network from one place to another so it is suffering from the major security concern. An electronic medical record (EMR) stores personal data which includes medical test results, prescription, hospitalizations, etc. Privacy in the ehealth system can be classified into two categories; Content oriented privacy and contextual privacy (2). So eHealth system can be termed as a secure system if it can deal with both these aspects of privacy. Content oriented privacy indicates the capability or authority of the health care stakeholders in disclosing the patients personal information to other parties (marketing, insurance) whereas contextual privacy indicates the ability of a malicious entity to guess the disease of a patient correctly by identifying the field/domain of his physician. Background In earlier days physicians used to use paper charts for recording the encounters with the patient. Details about medications, lab tests, X-rays etc the patient has taken, needs to be recorded in the chart for future reference. As the medical care became more and more complex, it became tedious for physicians to maintain a good patient record on these paper charts. They needed new technologies to help them to cope up with the increasing needs. With the advancement in the information and communication technologies, the idea of storing the patient records electronically came in around 1960s, when Dr. Lawrence Weed introduced the concept of Electronic Health Record. Weeds innovation allowed a third party to verify the diagnosis to avoid any errors. In 1972, Regenstreif Institute developed first medical record system which combined both inpatient and outpatient data recording (3). Electronic Health Records (EHR) Systems stores the entire health and medical history of a patient in a computerized, electronic format. The record includes the details about patient demographics, progress notes, medications, past medical history, vital signs, laboratory data, immunizations and radiology reports. Keeping these vast records in this organized manner, makes it more efficient to retrieve and maintain, when compared to the paper charts (4). As the medical care and the information technology became more and more complex, it became necessary to share the patient records among the various medical departments like clinical, nursing, laboratory, radiology, hospital administration etc in order to maintain a proper medical record about the patient. When the health records including sensitive data about the patient were shared electronically among the different departments, privacy and security problems became a major challenge to the EHR systems. The recent studies on security and privacy concerns in EHR systems shows that, there is increasing number of threats resulting from the distributed and decentralized implementations of EHR Systems, and also the use of communication over open and insecure internet. Unauthorized accesses, Denial of service are to name a few. Lack of standardization among these systems made it very difficult for the system administrators to implement a secure system (5). Research Problem The main problem associated with an eHealth system is the privacy, security and confidentiality of Electronic Health data (EHD). EHD stores private and sensitive data of the patient and data of EHD is used by physicians, nursing, laboratory, and pharmacy. The publication of personal sensitive data can seriously compromise the patient privacy. Due to this reason many individual does not go for eHealth treatment since they are afraid of the loss of their Health record including information about their illness or disability. In a survey conducted in Canada, it has been found out that 11-13% of Canadians have held back information from a health provider because they were afraid of the privacy of their data (6). In a survey conducted in America, 77% of the population is concerned about their medical information being used for marketing purposes (7). We are trying to figure out the peoples concern about the privacy of their health care record at Stockholm. We will examine the opinion of pu blic regarding the privacy of their health information and accessing eHealth service. Question The research questions drawn from the above problem set are: To what extent, privacy of health care records affects the individuals decision of accessing eHealth service? Are there certain groups of people for whom the privacy is a major issue while accessing the eHealth service? Goal The purpose of conducting this research is to examine the present scenario of the Health care system in Sweden. Research result will be helpful for patient, health care professionals and health care organizations. How the present scenario related to the privacy and the confidentiality of the Health care data is affecting the decision of accessing the eHealth Service. This survey will help to reveal the importance of Security in this field. Method In this section, we presented the description of the research methodology conducted in this paper, followed by the limitations of the research carried out and the reasons of such limitation. Method Description We are going to select inductive reasoning method for our research work. We will draw generalized conclusions from a finite collection of specific observations. Literature Review previous studies: we will study different literatures in the form of research reports and surveys which is conducted on EHR privacy in different parts of the world and then we will identify the present challenges related to patient privacy in Electronic health. Survey: we will formulate a questionnaire based on the identified privacy challenges and conduct a survey among the public to collect data. The questionnaire will be around 10-15 questions which will mainly focus on the awareness of e-health privacy among patients. The sample size for our survey will be around 100-150. Also we are planning to use the facts and figures available in the Internet as a secondary data source for our research. Suggested below are some of samples Do you think that your doctor should be able to access all your medical record in order to provide the best care? Are you willing to share your personal medical information to help government officials to research on disease outbreaks? Do you think that you should be able to access all of your medical records to verify the correctness of the medical record? How concerned are you about your medical records being used by marketing agencies? Formulating the Guidelines: Analyze the data collected, to derive a statistics on the research questions. We will be using IBMs SPSS tool to analyze the data collected and derive the statistics based on it. This statistics will help to find out how much the people are concerned about the privacy in EHR systems. Revising the guidelines: Based on the statistics, draw a conclusion and suggest ways to improve the privacy of patients sensitive data in e-Health. Report writing: The report will be constructed detailing the privacy challenges in EHR system and will point out the feasible suggestions. Limitations Because of the time constraint, the population that we are targeting for this survey includes only undergraduates, graduates, post graduates and post doctoral students (age group 18-35) in KTH (both Main Campus and Kista Campus). We are conducting this survey on limited range of age group, so the result will not include the opinion of elder citizens.

Dell Computers :: Computers History Historical Essays

Dell Computers Dell Computers was founded by Michael Dell, who started selling personal computers out of his dorm room as a freshman at the University of Texas. Michael Dell would buy parts wholesale, assembled them into clones (exact replicas) of IBM computers, and sold them by mail order to customers who did not want to pay the higher prices charged by retailers. Michael Dell was soon making 80,000 dollars a month profit and in 1984 Michael dropped out of university to found Dell Computers. Michael formed in his dorm room the underlying principles, which he would follow throughout the 80’s and 90’s as CEO of Dell Computers. Since their inception in 1982, dell has had a consistent rise in sales. Dells built to order strategy has enabled them to become a very efficient producer of computers and profitable company. The WebPages for dell computers has enabled dell to be able to reduce expenditures and become more efficient in their overall production and distribution of their products. Dell has been the only company to become an efficient maker of computers using the built-to-order system. Dells stock has become increasingly more valuable to investors over the past five years. Dell’s built-to-order strategy has made them successful in growth, development and stock valuation.   Ã‚  Ã‚  Ã‚  Ã‚  The book â€Å"Direct from Dell† gave a lot of background information on, Dell’s strategy, and mail order system as well as statistics on company sales and growth. The book goes into depth when analyzing Dell’s built-to-order system, and mail order system. The book was written before the WebPages became popular so it talks only about what the company expects from it and not about how the web page has performed. The Charles Shwabb investment web page gave a lot of information, which would suit potential investors on Dell. The web page allowed me to view Dell’s financial statements and analyze just how profitable Dell Computers has been and in which areas they showed the most or least profit. The book â€Å"The Market Share Reporter† gave me information on how much of the market Dell controls for each product they sell and how they compare to other companies. The book has many graphs, and charts to make it easier to see how much co ntrol a particular company has in that area in relation to other competing companies. Selling computers over the Internet enables Dell to become a more efficient distributor of computers.

Human Inequality :: essays research papers

Nothing in life is guaranteed, but there is one thing that we all expect to receive throughout our lifetime. Every human demands to be treated equally in the same manner as the person next to them. This general consensus of modern day was not the norm throughout the history of America. No matter how much we try not to look back upon our obtuse behavior towards particular ethnic groups, what took place cannot be undone. The only positive effect that can be derived from the past is to learn from these mistakes. Less than a century after abolishing what had become a two hundred year old practice of enslaving African Americans, the â€Å"Land of the Free† again displayed its disregard for human equality as Japanese Americans were stripped of their every belonging and sent to internment camps during World War II. The enslavement of African Americans began during a time when the United States was a budding country in the need for cheap labor. In response to this necessity, slave traders would go to various regions within Africa to hunt for the residents who they would then capture and sell. It is mind-blowing to imagine an entire family being taken from their home in chains, only to then be separated never to see one another again. These Africans were not only robbed of their family and home but also their freedom and right to live their own lives. Upon their arrival to America, along with the new title of African Americans, came a new life of cruelty and inhumanity. Their self-respect was the first thing to be disposed of as they were assigned a monetary value when auctioned off like prize cattle. In Jacobs’ Incidents in the Life of a Slave Girl, the author describes the sale of her uncle with, â€Å"Though only ten years old, seven hundred and twenty dollars was paid for him.† This was only the beginning of the slaveholders’ attempt to confiscate any remnant piece of dignity so that the slaves could be more easily oppressed. Slaveholders recognized the potential that knowledge created within a person and thus, kept their slaves as ignorant as possible. Because literacy was not allowed by any means, slaves were deprived of the celebrated joy of a birthday. Douglass describes in Narrative of the Life of an American Slave, slaves’ inability to know their own birthday because there were no authentic records considering nobody was able to read or write.

Dr. John Henry doc Holliday :: essays research papers

On August 14, 1851 in Griffin, Georgia, John Henry Holliday was born to Henry Burroughs and Alice Jane Holliday. Their first child, Martha Eleanora, had died on June 12, 1850 at six months of age. When he married Alice Jane McKay on January 8, 1849, Henry Burroughs was a druggist by trade and, later became a wealthy planter, lawyer, and during the War between the States, a Confederate Major. Church records state: "John Henry, infant son of Henry B. and Alice J. Holliday, received the ordinance of baptism on Sunday, March 21, 1852, at the First Presbyterian Church in Griffin." Alice Jane died on September 16, 1866. This was a terrible blow to young John Henry for he and his mother were very close. To compound this loss, his father married Rachel Martin only three months later on December 18, 1886. Shortly after this marriage, the Holliday family moved to Valdosta, Georgia. Major Holliday quickly became one of the town's leading citizens, becoming Mayor, the Secretary of the County Agricultural Society, a Member of the Masonic Lodge, the Secretary of the Confederate Veterans Camp, and the Superintendent of local elections. Because of his family status, John Henry had to choose some sort of profession and he chose dentistry. He enrolled in dental school in 1870 and attended his first lecture session in 1870-1872. Each lecture session lasted a little over three months. He served his required two years apprenticeship under Dr. L.F. Frank. On March 1, 1872, the Pennsylvania College of Dental Surgery in Philadelphia conferred the degree of Doctor of Dental Surgery upon twenty-six men, one of whom was John Henry Holliday. Upon completion of his training and graduation, Dr. Holliday opened an office with a Dr. Arthur C. Ford in Atlanta in 1872. Then, because of the session of the Southern Dental Association, Dr. Arthur C. Ford, D.D.A. was unable to serve patients, until the middle of August. Taking his place was Doc Holliday. John was a good dentist, but shortly after starting his practice, he discovered that he had contracted tuberculosis. Although he consulted a number of doctors, the consensus of all was that he had only months to live. However, they all concurred that he might add a few months to his life if he moved to a dry climate. Following this advice, Doc packed up and headed West. His first stop was in Dallas, Texas, the end of the railroad at the time. Dr. John Henry doc Holliday :: essays research papers On August 14, 1851 in Griffin, Georgia, John Henry Holliday was born to Henry Burroughs and Alice Jane Holliday. Their first child, Martha Eleanora, had died on June 12, 1850 at six months of age. When he married Alice Jane McKay on January 8, 1849, Henry Burroughs was a druggist by trade and, later became a wealthy planter, lawyer, and during the War between the States, a Confederate Major. Church records state: "John Henry, infant son of Henry B. and Alice J. Holliday, received the ordinance of baptism on Sunday, March 21, 1852, at the First Presbyterian Church in Griffin." Alice Jane died on September 16, 1866. This was a terrible blow to young John Henry for he and his mother were very close. To compound this loss, his father married Rachel Martin only three months later on December 18, 1886. Shortly after this marriage, the Holliday family moved to Valdosta, Georgia. Major Holliday quickly became one of the town's leading citizens, becoming Mayor, the Secretary of the County Agricultural Society, a Member of the Masonic Lodge, the Secretary of the Confederate Veterans Camp, and the Superintendent of local elections. Because of his family status, John Henry had to choose some sort of profession and he chose dentistry. He enrolled in dental school in 1870 and attended his first lecture session in 1870-1872. Each lecture session lasted a little over three months. He served his required two years apprenticeship under Dr. L.F. Frank. On March 1, 1872, the Pennsylvania College of Dental Surgery in Philadelphia conferred the degree of Doctor of Dental Surgery upon twenty-six men, one of whom was John Henry Holliday. Upon completion of his training and graduation, Dr. Holliday opened an office with a Dr. Arthur C. Ford in Atlanta in 1872. Then, because of the session of the Southern Dental Association, Dr. Arthur C. Ford, D.D.A. was unable to serve patients, until the middle of August. Taking his place was Doc Holliday. John was a good dentist, but shortly after starting his practice, he discovered that he had contracted tuberculosis. Although he consulted a number of doctors, the consensus of all was that he had only months to live. However, they all concurred that he might add a few months to his life if he moved to a dry climate. Following this advice, Doc packed up and headed West. His first stop was in Dallas, Texas, the end of the railroad at the time.

9th Grade Biology

Biology Chapter 17 1) 17. 1 Protists are the Most Diverse of All Eukaryotes a. Slide 1: Complex Characteristics of Protists i. Protist 1. eukaryotic organism that is not an animal, a plant, or a fungus ii. Structure iii. Future iv. Examples v. Classification b. Slide 2: Complex Cells/Grouping by Nutrition vi. Heterotroph/Autotrophs vii. How to Group: viii. Animal-Like 2. Protozoans a. animal-like protist; is a heterotroph ix. Fungus-Like x. Plant-Like 3. Algae b. plant-like protist; makes its own food by photosynthesis Read also Lab 2 Biology 2) 17. Protozoans Digest their Food c. Slide 1: Protozoans With Flagella xi. Zooflagellates c. member of a group of protozoans that move by means of one or more flagella 4. Reproduction 5. Giardia 6. Trypanosoma d. Slide 2: Protozoans With Pseudopodia xii. Amoebas: 7. Movement: pseudopodia d. temporary extension of a cell's cytoplasm and plasma membrane; used by certain protozoans in movement and feeding 8. Forarms e. member of a group of marine protozoans with porous shells made of organic material and calcium carbonate   e.Slide 3: Protozoans with Cilia xiii. Paramecium 9. Movement f. Ciliates i. member of a group of protozoans that move and feed by means of hair like projections f. Slide 4: Protozoans Lacking Motility xiv. Apicomplexans (parasites) 10. Plasmodium g. Malaria 3) 17. 3 g. Plasmodia Slime Molds 11. member of a group of fungus-like protists that grows in a branching pattern xv. Cellular Slime Mold 12. protist with both unicellular and multicellular stages in its life cycle; is a decomposer xvi. Plasmodium 13. ember of a group of fungus-like protists that grows in a branching pattern xvii. Sporangia 14. reproductive structures on a plasmodial slime mold; also called fruiting bodies h. Water Molds and Downy Mildews xviii. Water molds xix. Downy mildews 15. Phytophthora Infestans 4) 17. 4 i. Euglenoids 16. member of a group of unicellular photosynthetic protists with one or two flagella and no cell wall xx. Euglena j. Dinoflagellates 17. member of a group of unicellular, photosynthetic algae with cell walls made of cellulose and having two flagella xxi.Plankton 18. mostly microscopic organisms that drift or swim near the surface of ponds, lakes, and ocean xxii. Phytoplankton 19. microscopic algae and cyanobacteria that carry out photosynthesis   xxiii. Zooplankton 20. microscopic animals that swim or drift near the surface of aquatic environments k. Diatoms 21. member of a group of unicellular algae with glasslike cell walls l. Seaweeds 22. a la rge, multicellular marine alga xxiv. Brown Algae xxv. Red Algae xxvi. Green AlgaeGeneral Biology Ii Study Guide (Online Class)

Broken Family Essay

Family is the basic unit of society. This is the most essential component of a country. Governance will only be effective if the citizens are properly oriented with good values and virtues, which is commonly taught by the family. A home is where a family lives. It may be alternated to the word ‘house’ but a house is more appropriately referring to the material structure, whereas ‘home’ refers to the intangible things that bind together the family members. It is the immeasurable love and care that keeps together the mother, father and their children. However, no matter how ideal a family in the terms of their relationship, there are still hardships and misunderstandings that will come along the way. It is just part of any relationship anyway. But, the sad part is when one of the family members gave up and the others have no choice but to accept and let go. Thus, the family starts to be broken. Broken Family is a family with children involved where parents are legally or illegally separated†¦whose parents have decided to go and live their lives separately for several reasons/problems. Too many arguments that might lead to divorce and the parents divide their children. But I believe its mostly cause by drugs or money. Too much money leads to arguments and greediness which causes to forget about love and divorce. Too poor leads to depression and arguments and feels like they have to split up and start over. Drugs messes with someones head and they mostly die or the family leaves that person behind for the cause of the children’s growing. But its not all parents, some teenagers runs away from home, of course, with their own reasoning. Some parent’s children die and it causes them to split. For the cause of the child’s growing, they divorce and find some place else . Or sometimes, its work. Not working too much or a workaholic may lead up for a broken family. Or if someone dies, then of course they’re broken inside the most. Though your answer is very good, I think you miss one detail. Another cause for a broken family, is abuse. Maybe the parents or parent hits the kids, and wife. Or maybe the son hits the parents. I think that is a very big reason in why many family’s are broken. Yes, still there’s one detail also that you may include, when the relatives of each party join to the problem or favors a parties (and sometimes it’s the parents of each party will suggest to them to separate). Or because the husband or wife having an affair. That’s why many FAMILIES break up. maybe one of the reasons of family breake up is the wife is very secretive to his husband for all times, and lack of trust in each parties. And there’s one more if the wife didn’t respect there husband due to high salary compare to a head of the family there will be conflict. And guys lastly Jealousy is one of the big reason why there’s so many BROKEN FAMILY, but its OK if the wife understands the husband feelings and avoid the person that he’ jealous of. But if not we are guys only knows what is the next part of our lives.